Article

Single molecule imaging of the central dogma reveals myosin-2A gene expression is regulated by contextual translational buffering

2024-02-11

Abstract excerpt

While protein homeostasis is a hallmark of gene regulation, unraveling the hidden regulatory mechanisms that maintain homeostasis is difficult using traditional methods. To confront this problem, we CRISPR engineered a human cell line with multiple tags in the endogenous MYH9 gene, which encodes the essential and ubiquitous myosin-2A cytoskeletal motor. Using these cells, we imaged MYH9 transcription, translation,...

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Literature Corpus work: 1ad995bd-9af4-5448-803f-52d703f46d69
DOI: 10.1101/2024.02.11.579797

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Single molecule imaging of the central dogma reveals myosin-2A gene expression is regulated by contextual translational bufferingDOI 10.1101/2024.02.11.579797Read

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