Article

The kinetic landscape of human transcription factors

2022-06-02

Abstract excerpt

Cell-to-cell variability is shaped by transcription dynamics because genes are transcribed in bursts interspersed with inactive periods. The stochasticity of bursting means that genes transcribed in rare bursts exhibit more heterogeneity at the single cell level than genes that burst often 1, 2 . Transcription starts with the binding of Transcription Factors (TFs) to specific sequence motifs where they recruit th...

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Literature Corpus work: 2c166e45-e8ba-53b5-903f-e62f4cc15def
DOI: 10.1101/2022.06.01.494187

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