Back to search

Article

A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosis

2024-07-04

Abstract excerpt

<h4>Background: </h4> Alzheimer's Disease (AD) is characterized by progressive amyloid beta (Aβ) deposition in the brain, with eventual widespread neurodegeneration. While the cell-specific molecular signature of end-stage AD is reasonably well characterized through autopsy material, less is known about the molecular pathways in the human brain involved in the earliest exposure to Aβ. Human model systems that not...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ca9d2330-e361-5bd0-b5aa-b7adc3f0b3ef
DOI
10.1101/2024.07.01.601570
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosisDOI 10.1101/2024.07.01.601570
A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosisSemantic proximity
Modeling Alzheimer’s Disease with APOE4 Neuron-Glial Brain Assembloids Reveals IGFBPs as Therapeutic TargetsSemantic proximity
Unveiling the Impact of Microglial Cells in Alzheimer's Disease Pathogenesis: Insights from Single-Cell RNA-seq Analysis and In Vivo ValidationSemantic proximity
Glial and Neuronal Alzheimer's Disease-Related Alterations Reproduced in Human Induced Pluripotent Stem Cells With Presenilin-1 MutationSemantic proximity
Single-cell and nucleus RNA-seq in a mouse model of AD reveal activation of distinct glial subpopulations in the presence of plaques and tanglesSemantic proximity
A reproducible human brain tissue model to study physiological and disease-associated microglia phenotypesSemantic proximity
iPSC-Derived PSEN2 (N141I) Astrocytes and Microglia Exhibit a Primed Inflammatory PhenotypeSemantic proximity
Microglia Heterogeneity in Alzheimer’s Disease: Insights From Single-Cell TechnologiesSemantic proximity
A resource for generating and manipulating human microglial states in vitroSemantic proximity
The TREM2-R47H Variant Drives Alzheimer’s-Relevant Alterations in Forebrain Organoids Beyond Microglial PopulationsSemantic proximity
New Human IPSC Models of Late-onset Alzheimer’s Disease Polygenic Risk Identify Multiple Impairments of Microglial FunctionSemantic proximity
Reprogramming the Brain—iPSC Models Illuminating the Pathogenesis and Treatment of Alzheimer’s Disease and Other DementiasSemantic proximity
Select a neighboring publication to make it the new centre.