Article
Unveiling the Impact of Microglial Cells in Alzheimer's Disease Pathogenesis: Insights from Single-Cell RNA-seq Analysis and In Vivo Validation
2024-01-19
Abstract excerpt
Alzheimer's disease (AD), a prevalent global cause of dementia lacking a cure, has traditionally been studied from a molecular perspective. However, our investigation delved into the intricate cellular dimensions of AD, focusing on microglial cells, the primary immune cells in the central nervous system (CNS). Through a single-cell approach using scRNA-seq, we revealed an increased presence of microglial cells in...
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Identifiers and source
- Literature Corpus work
- 48322951-6e00-529a-9c18-1577367d3039
- DOI
- 10.21203/rs.3.rs-3796551/v1