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A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosis

24 Apr 2025

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is characterized by progressive amyloid beta (Aβ) deposition in the brain, with eventual widespread neurodegeneration. While the cell-specific molecular signature of end-stage AD is reasonably well characterized through autopsy material, less is known about the molecular pathways in the human brain involved in the earliest exposure to Aβ. Human model systems that not only...

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PMID: 40275379
DOI: 10.1186/s12974-025-03433-3

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