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The TREM2-R47H Variant Drives Alzheimer’s-Relevant Alterations in Forebrain Organoids Beyond Microglial Populations

2026-02-26

Abstract excerpt

Recent genetic studies highlight microglia as central drivers of Alzheimer’s disease (AD), yet how specific risk variants like TREM2-R47H influence broader neurocellular networks remains elusive. Here, we utilize an iPSC-derived forebrain organoid co-culture system to investigate the multi-lineage impact of the TREM2-R47H variant. High-resolution transcriptomic profiling, paired with confocal imaging, demonstrat...

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Literature Corpus work
83f372dd-22c5-590b-9953-665cbc6b1cb9
DOI
10.64898/2026.02.25.706648
Open publication

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The TREM2-R47H Variant Drives Alzheimer’s-Relevant Alterations in Forebrain Organoids Beyond Microglial PopulationsDOI 10.64898/2026.02.25.706648
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