Article

New Human IPSC Models of Late-onset Alzheimer’s Disease Polygenic Risk Identify Multiple Impairments of Microglial Function

2026-05-01

Abstract excerpt

Genetic discoveries implicate microglia in late-onset Alzheimer’s disease (AD). We modelled AD in a powerful study of 51 human induced pluripotent stem cell (iPSC) microglia derived from high-polygenic risk AD or low-risk cognitively well individuals, sampled from a large cohort. We explored mitochondrial function, cytokine secretion, endocytosis, phagocytosis, lipid accumulation, calcium store release, and chemot...

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Literature Corpus work: babf3953-f2ec-5309-9cf8-7fe71d35cd68
DOI: 10.64898/2026.04.29.721607

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