Article
A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes.
Nature neuroscience - 1 Sept 2026
Klimmt Julien, Cardoso Gonçalves Carolina, Montgomery Jessica Valentina, Müller Stephan A, Bublitz Merle, Filser Severin, Paeger Lars, Nuscher Brigitte, Dannert Angelika, Roeber Sigrun, Pravata Veronica, Schifferer Martina, Shrouder Joshua J, Schulz Nathalie, González-Gallego Judit, Cappello Silvia, Misgeld Thomas, Plesnila Nikolaus, Beltrán Eduardo, Herms Jochen, De Domenico Elena, Beyer Marc D, Schultze Joachim L, Haass Christian, Lichtenthaler Stefan F, Carraro Caterina, Paquet Dominik
Abstract excerpt
Stem-cell-based in vitro models offer promising potential to elucidate human brain cell functions and interactions, but limitations in reproducibility, maturation and cell-type diversity persist. Especially, prolonged incorporation of mature microglia and studies of neuroinflammation have proven challenging. Here, we developed a human induced pluripotent stem cell-based three-dimensional cortical brain tissue...
Read the complete abstract on PubMedTopics
- Humans
- Microglia
- Alzheimer Disease