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Article

iPSC-Derived PSEN2 (N141I) Astrocytes and Microglia Exhibit a Primed Inflammatory Phenotype

2022-12-05

Abstract excerpt

<h4>Background</h4> Widescale evidence points to the involvement of glia and immune pathways in the progression of Alzheimer’s disease (AD). AD-associated iPSC-derived glial cells show a diverse range of AD-related phenotypic states encompassing cytokine/chemokine release, phagocytosis and morphological profiles, but to date studies are limited to cells derived from PSEN1, APOE and APP mutations or sporadic patie...

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Literature Corpus work
62f3d36e-1e60-5e47-bc75-aadd29ddb527
DOI
10.1101/2022.12.05.518134
Open publication

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iPSC-Derived PSEN2 (N141I) Astrocytes and Microglia Exhibit a Primed Inflammatory PhenotypeDOI 10.1101/2022.12.05.518134
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