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Modeling Alzheimer’s Disease with APOE4 Neuron-Glial Brain Assembloids Reveals IGFBPs as Therapeutic Targets

2025-10-19

Abstract excerpt

<h4>SUMMARY</h4> Alzheimer’s disease (AD) research has been hindered by the lack of models that faithfully recapitulate the full profile of disease progression in a human genetic background. We developed a 3D assembloid model (“Masteroid”) using iPSC-derived neurons, astrocytes, and microglia from APOE4/4 and isogenic control lines. Neurons were seeded with tau oligomers, then combined with astrocytes and microgl...

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Literature Corpus work
cf1929bb-5dff-578b-b59f-c8a73fddc62a
DOI
10.1101/2025.10.17.683162
Open publication

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Modeling Alzheimer’s Disease with APOE4 Neuron-Glial Brain Assembloids Reveals IGFBPs as Therapeutic TargetsDOI 10.1101/2025.10.17.683162
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