Article
Functional characterization of Alzheimer's disease genetic variants in microglia.
Nature genetics - 1 Oct 2023
Yang Xiaoyu, Wen Jia, Yang Han, Jones Ian R, Zhu Xiaodong, Liu Weifang, Li Bingkun, Clelland Claire D, Luo Wenjie, Wong Man Ying, Ren Xingjie, Cui Xiekui, Song Michael, Liu Hongjiang, Chen Cady, Eng Nicolas, Ravichandran Mirunalini, Sun Yang, Lee David, Van Buren Eric, Jiang Min-Zhi, Chan Candace S Y, Ye Chun Jimmie, Perera Rushika M, Gan Li, Li Yun, Shen Yin
Abstract excerpt
Candidate cis-regulatory elements (cCREs) in microglia demonstrate the most substantial enrichment for Alzheimer's disease (AD) heritability compared to other brain cell types. However, whether and how these genome-wide association studies (GWAS) variants contribute to AD remain elusive. Here we prioritize 308 previously unreported AD risk variants at 181 cCREs by integrating genetic information with...
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