Article

Integration of Alzheimer’s GWAS, 3D genomics, and single-cell CRISPRi non-coding screen implicates causal variants in a microglial enhancer regulating TSPAN14

2025-04-01

Abstract excerpt

<h4>ABSTRACT</h4> While GWAS have been successful in providing variant-to-trait associations for human complex diseases, functional dissection of the discovered loci has lagged behind. Here, we describe a variant-to-gene (V2G) mapping effort for Alzheimer’s disease (AD) to implicate causal variants and effector genes from the most recent AD GWAS meta-analyses (101 loci). We leveraged our genomics datasets compris...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aeccd3c4-a712-5e6c-8397-80c5038e64d6
DOI: 10.1101/2025.04.01.646442

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integration of Alzheimer’s GWAS, 3D genomics, and single-cell CRISPRi non-coding screen implicates causal variants in a microglial enhancer regulating TSPAN14DOI 10.1101/2025.04.01.646442Read

Integrative genomics and single-cell CRISPRi screening dissect Alzheimer GWAS non-coding variants regulating TSPAN14.Semantic proximity Read

Functional characterization of Alzheimer's disease genetic variants in microglia.Semantic proximity Read

Variant-to-function mapping of late-onset Alzheimer’s disease GWAS signals in human microglial cell models implicates RTFDC1 at the CASS4 locusSemantic proximity Read

Integrated genomic analysis and CRISPRi implicatesEGFRin Alzheimer’s disease riskSemantic proximity Read

Regulatory landscape of Alzheimer’s disease variants in human microgliaSemantic proximity Read

Integrative genomic and transcriptomic analysis identifies microglia-expressed genes with causal links to Alzheimer's disease risk.Semantic proximity Read

Genetics of the human microglia regulome refines Alzheimer’s disease risk lociSemantic proximity Read

Single-cell epigenomic identification of inherited risk loci in Alzheimer’s and Parkinson’s diseaseSemantic proximity Read

Cell type-specific enhancer-promoter connectivity maps in the human brain and disease risk associationSemantic proximity Read

An integrated toolkit for human microglia functional genomicsSemantic proximity Read

Genetic risk for neurodegenerative conditions is linked to disease-specific microglial pathwaysSemantic proximity Read

An Alzheimer’s disease-associated common regulatory variant in a PTK2B intron alters microglial functionSemantic proximity Read

Integration of Alzheimer’s GWAS, 3D genomics, and single-cell CRISPRi non-coding screen implicates causal variants in a microglial enhancer regulating <i>TSPAN14</i>

Abstract excerpt

Topics

Identifiers and source

Related research