Article

Regulatory landscape of Alzheimer’s disease variants in human microglia

2025-10-15

Abstract excerpt

Genome-wide association studies (GWAS) for Alzheimer’s disease (AD) predominantly implicate non-coding genetic variants that are presumed to regulate gene expression. Yet, around half of GWAS variants do not coincide with known regulatory variants, such as expression quantitative trait loci (eQTLs). AD GWAS loci are enriched for microglia-specific regulatory regions, but the causal variants and mechanisms remain u...

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Literature Corpus work: d0e0f9f3-49f5-5d5a-bb8c-a3ec4fb57d2e
DOI: 10.1101/2025.10.13.25337902

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