Article

Genetics of the human microglia regulome refines Alzheimer’s disease risk loci

2021-10-18

Abstract excerpt

Microglia are brain resident myeloid cells that play a critical role in neuroimmunity and the etiology of Alzheimer’s Disease (AD). Yet our understanding of how the genetic regulatory landscape controls microglial function and contributes to disease is limited. Here, we performed transcriptome and chromatin accessibility profiling in primary human microglia from 150 donors to identify genetically-driven variation...

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Literature Corpus work: ae7e32be-bfd2-590a-8b06-b48a06356179
DOI: 10.1101/2021.10.17.21264910

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