Article

KOLF2.1J iTF-Microglia: A standardized platform to study microglial transcriptional regulatory networks in CNS disease

2025-06-03

Abstract excerpt

<h4>Summary</h4> Understanding transcriptional regulatory networks (TRNs) in microglia is key to uncovering mechanisms driving central nervous system (CNS) disorders. Human iPSC-derived models offer a tractable system for studying microglia, yet variability between lines has limited reproducibility. Here, we use the standardized KOLF2.1J iTF line to rapidly generate microglia-like cells (iTF-Microglia) and profil...

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Literature Corpus work: 0990c823-d147-5eeb-9265-ddb8d81875d7
DOI: 10.1101/2025.05.30.657077

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