Article
Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes.
Nature communications - 12 Mar 2021
Novikova Gloriia, Kapoor Manav, Tcw Julia, Abud Edsel M, Efthymiou Anastasia G, Chen Steven X, Cheng Haoxiang, Fullard John F, Bendl Jaroslav, Liu Yiyuan, Roussos Panos, Björkegren Johan Lm, Liu Yunlong, Poon Wayne W, Hao Ke, Marcora Edoardo, Goate Alison M
Abstract excerpt
Genome-wide association studies (GWAS) have identified more than 40 loci associated with Alzheimer's disease (AD), but the causal variants, regulatory elements, genes and pathways remain largely unknown, impeding a mechanistic understanding of AD pathogenesis. Previously, we showed that AD risk alleles are enriched in myeloid-specific epigenomic annotations. Here, we show that they are specifically enriched in...
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