Article

Deciphering the functional impact of Alzheimer’s Disease-associated variants in resting and proinflammatory immune cells

2024-09-16

Abstract excerpt

Genome-wide association studies have identified loci associated with Alzheimer’s Disease (AD), but identifying the exact causal variants and genes at each locus is challenging due to linkage disequilibrium and their largely non-coding nature. To address this, we performed a massively parallel reporter assay of 3,576 AD-associated variants in THP-1 macrophages in both resting and proinflammatory states and identifi...

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Literature Corpus work: 1d82c232-c2a2-5efd-8eff-ef5acf042572
DOI: 10.1101/2024.09.13.24313654

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