Article

Neuronal and microglial fine-tuned 3D DNA foundation models dissect genetic variants in Alzheimer’s disease

2026-02-26

Abstract excerpt

<title>Abstract</title> <p> Although genetic variants are among the strongest risk factors for Alzheimer’s disease (AD), most associated variants reside in non-coding regions with unclear mechanisms. Here, we address that gap by fine-tuning the Akita DNA foundation model on high-resolution Hi-C data generated from neuronal progenitor cells (NPCs) and microglia to produce <italic>iNeuroAkita</italic> , a cell-c...

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Literature Corpus work: 98d55c1b-e16a-5d43-8fe3-7be882ee2183
DOI: 10.21203/rs.3.rs-8920766/v1

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