Article

Context-dependent regulatory variants in Alzheimer’s disease

2025-07-11

Abstract excerpt

Noncoding genetic variants underlie many complex diseases, yet identifying and interpreting their functional impacts remains challenging. Late-onset Alzheimer’s disease (LOAD), a polygenic neurodegenerative disorder, exemplifies this challenge. The disease is strongly associated with noncoding variation, including common variants enriched in microglial enhancers and rare variants nominated at loci implicated in ne...

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Literature Corpus work: bf0c05af-60da-584c-baad-cb3d1040ba50
DOI: 10.1101/2025.07.11.659973

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