Article

Alternative polyadenylation drives oncogenic gene expression in pancreatic ductal adenocarcinoma

2019-08-30

Abstract excerpt

<h4>ABSTRACT</h4> Alternative polyadenylation (APA) is a gene regulatory process that dictates mRNA 3’-UTR length, resulting in changes in mRNA stability and localization. APA is frequently disrupted in cancer and promotes tumorigenesis through altered expression of oncogenes and tumor suppressors. Pan-cancer analyses have revealed common APA events across the tumor landscape; however, little is known about tumor...

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Literature Corpus work: ca127fec-3fe1-507b-961e-dabfedaa5516
DOI: 10.1101/752295

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