Article

A pan-cancer interrogation of intronic polyadenylation and its association with cancer characteristics

2022-11-16

Abstract excerpt

<h4>ABSTRACT</h4> mRNA cleavage and polyadenylation is an integral 2-step process in the generation of protein-encoding mRNA or noncoding transcripts. More than 60% of human genes have multiple polyadenylation sites either in the 3’ untranslated region (3’UTR-APA) or in the intronic/exonic region, resulting in expression of isoforms with alternative polyadenylation (APA) under different physiologic conditions. Th...

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Literature Corpus work: ef945143-b59b-5f26-a594-55d0aa9ba102
DOI: 10.1101/2022.11.14.516018

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