Article

A distinct class of pan-cancer susceptibility genes revealed by alternative polyadenylation transcriptome-wide association study

2023-03-01

Abstract excerpt

Alternative polyadenylation (APA) plays an important role in cancer initiation and progression; however, current genome- and transcriptome-wide association studies (GWAS and TWAS, respectively) mostly ignore APA when identifying putative cancer susceptibility genes. Here, we performed a pan-cancer 3′untranslated region (UTR) APA TWAS (3′aTWAS) by integrating 80 well-powered ( n >50,000) GWAS datasets across 23 maj...

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Literature Corpus work: 90f46d6c-7415-5e35-b21b-66e3f7117423
DOI: 10.1101/2023.02.28.23286554

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