Article

CPSF3 inhibition blocks pancreatic cancer cell proliferation through disruption of core histone processing

2022-05-10

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited effective treatment options. This potentiates the importance of uncovering novel drug targets. We have discovered global dysregulation of the gene regulatory process alternative polyadenylation (APA) in PDAC. APA is a pre-mRNA processing mechanism that generates mRNAs with distinct 3’ ends, impacting gene expression and protein function. We r...

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Literature Corpus work: fda38c73-16e3-5cb9-a0f7-1937b6cc2843
DOI: 10.1101/2022.05.09.491230

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