Article

Shortening of 3’ UTRs in most cell types composing tumor tissues implicates alternative polyadenylation in protein metabolism

2021-07-01

Abstract excerpt

During pre-mRNA maturation 3’ end processing can occur at different polyadenylation sites in the 3’ untranslated region (3’ UTR) to give rise to transcript isoforms that differ in the length of their 3’UTRs. Longer 3’ UTRs contain additional cis-regulatory elements that impact the fate of the transcript and/or of the resulting protein. Extensive alternative polyadenylation (APA) has been observed in cancers, but t...

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Literature Corpus work: 73104bd9-0668-53ff-86d9-be20cbd2d59c
DOI: 10.1101/2021.06.30.450496

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