Article
Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma.
Gut - 1 Mar 2019
Arnes Luis, Liu Zhaoqi, Wang Jiguang, Maurer Carlo, Sagalovskiy Irina, Sanchez-Martin Marta, Bommakanti Nikhil, Garofalo Diana C, Balderes Dina A, Sussel Lori, Olive Kenneth P, Rabadan Raul
Abstract excerpt
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDA) is a highly metastatic disease with limited therapeutic options. Genome and transcriptome analyses have identified signalling pathways and cancer driver genes with implications in patient stratification and targeted therapy. However, these analyses were performed in bulk samples and focused on coding genes, which represent a small fraction of the genome. DESIGN:...
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