Article

A pan-cancer interrogation of intronic polyadenylation and its association with cancer characteristics

2022-12-01

Abstract excerpt

<title>Abstract</title> <p>3’UTR-APAs have been extensively studied, but IPAs remain largely unexplored. We characterized the profiles of 22,260 IPAs in 9,679 patient samples across 32 cancer types from the TCGA cohort. By comparing tumor and paired normal tissues, we identified 180~4,645 dysregulated IPAs in 132~2,249 genes in each of 690 patient tumors from 22 cancer types that showed consistent patterns within...

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Literature Corpus work: 64c48197-066d-5b0b-ab63-e9317a473bf0
DOI: 10.21203/rs.3.rs-2321147/v1

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