Article

Large-scale alternative polyadenylation (APA)-wide association studies to identify putative susceptibility genes in human common cancers

2023-11-07

Abstract excerpt

Alternative polyadenylation (APA) modulates mRNA processing in the 3’ untranslated regions (3’UTR), which affect mRNA stability and translation efficiency. Here, we build genetic models to predict APA levels in multiple tissues using sequencing data of 1,337 samples from the Genotype-Tissue Expression, and apply these models to assess associations between genetically predicted APA levels and cancer risk with data...

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Literature Corpus work: 0d9eed2f-c4f0-5ae8-b5d5-e92b31c91b8c
DOI: 10.1101/2023.11.05.23298125

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