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Large-Scale Alternative Polyadenylation-Wide Association Studies to Identify Putative Cancer Susceptibility Genes.

Cancer research - 15 Aug 2024

Guo Xingyi, Ping Jie, Yang Yaohua, Su Xinwan, Shu Xiao-Ou, Wen Wanqing, Chen Zhishan, Zhang Yunjing, Tao Ran, Jia Guochong, He Jingni, Cai Qiuyin, Zhang Qingrun, Giles Graham G, Pearlman Rachel, Rennert Gad, Vodicka Pavel, Phipps Amanda, Gruber Stephen B, Casey Graham, Peters Ulrike, Long Jirong, Lin Weiqiang, Zheng Wei

Abstract excerpt

Alternative polyadenylation (APA) modulates mRNA processing in the 3'-untranslated regions (3' UTR), affecting mRNA stability and translation efficiency. Research into genetically regulated APA has the potential to provide insights into cancer risk. In this study, we conducted large APA-wide association studies to investigate associations between APA levels and cancer risk. Genetic models were built to predict...

Topics

Humans
Genetic Predisposition to Disease
Polyadenylation
Genome-Wide Association Study
Neoplasms
3' Untranslated Regions
Quantitative Trait Loci
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Male

Gene Expression Regulation, Neoplastic

RNA, Messenger

Cell Line, Tumor

Source

Open in PubMed Open full text

Identifiers

PMID: 38759092
DOI: 10.1158/0008-5472.CAN-24-0521
PMCID: PMC11326986

Genes

DIP2B
FBXO38
LDHA
STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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