Article

Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging

2023-10-07

Abstract excerpt

Aβ peptides derived from the amyloid precursor protein (APP) have been strongly implicated in the pathogenesis of Alzheimer’s disease. However, the normal function of APP and the importance of that role in neurodegenerative disease is less clear. We recovered the Drosophila ortholog of APP, Appl, in an unbiased forward genetic screen for neurodegeneration mutants. We performed comprehensive single cell transcript...

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Literature Corpus work: c9b94e1b-c343-5351-83f2-75af32827da9
DOI: 10.1101/2023.10.06.560646

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