Article

Regulation of lipid dysmetabolism and neuroinflammation progression linked with Alzheimer’s disease through modulation of Dgat2

2025-02-19

Abstract excerpt

Alzheimer’s disease (AD), an age-associated neurodegenerative disorder, is characterized by progressive cognitive decline, amyloid-β (Aβ) deposition, lipid dysregulation, and neuroinflammation. Although mutations in the amyloid precursor protein (APP) and accumulation of Aβ42 are established drivers of pathology, the mechanisms connecting amyloid toxicity with lipid metabolism and inflammatory responses remain poo...

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Literature Corpus work: a0f0d428-c248-5910-a4ed-80209f9f3ed8
DOI: 10.1101/2025.02.18.638929

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