Article
Identification of novel modifiers of Aβ toxicity by transcriptomic analysis in the fruitfly.
Scientific reports - 16 Dec 2013
Favrin G, Bean D M, Bilsland E, Boyer H, Fischer B E, Russell S, Crowther D C, Baylis H A, Oliver S G, Giannakou M E
Abstract excerpt
The strongest risk factor for developing Alzheimer's Disease (AD) is age. Here, we study the relationship between ageing and AD using a systems biology approach that employs a Drosophila (fruitfly) model of AD in which the flies overexpress the human Aβ42 peptide. We identified 712 genes that are differentially expressed between control and Aβ-expressing flies. We further divided these genes according to how they...
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