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Isogenic cortical organoids enable precision targeting of APP variant-specific pathways in Alzheimer’s disease

2026-02-20

Abstract excerpt

Alzheimer’s disease (AD) lacks disease-modifying therapies, in part due to the limitations of existing disease models, which have struggled to capture the early pathogenic events leading to neuronal degeneration. Unfortunately, recent therapies targeting hallmarks of AD have proven inefficient in humans, and it is thus necessary to identify alternative targets. Here, by generating an isogenic panel of hiPSC-derive...

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Literature Corpus work
f455748f-bf37-50e7-901e-c0b2bc4e1232
DOI
10.64898/2026.02.19.706886
Open publication

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Isogenic cortical organoids enable precision targeting of APP variant-specific pathways in Alzheimer’s diseaseDOI 10.64898/2026.02.19.706886
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