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Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging

3 Nov 2023

Abstract excerpt

Aβ peptides derived from the amyloid precursor protein (APP) have been strongly implicated in the pathogenesis of Alzheimer's disease. However, the normal function of APP and the importance of that role in neurodegenerative disease is less clear. We recover the Drosophila ortholog of APP, Appl, in an unbiased forward genetic screen for neurodegeneration mutants. We perform comprehensive single cell...

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PMID: 37923712
DOI: 10.1038/s41467-023-42822-1

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