Exploring the multifaceted functions of APPL in metabolism and memory using Drosophila melanogaster.

Abstract excerpt

Amyloid precursor protein (APP) is a single-pass transmembrane protein abundantly expressed in the central nervous system and implicated in familial Alzheimer's disease, a progressive neurodegenerative disorder that impairs memory. Here, we investigated the role of amyloid precursor protein-like (APPL) using the model organism Drosophila melanogaster. In this study, Appl null mutants exhibited a reduced lifespan...

Topics

• Animals
• Drosophila melanogaster
• Memory
• Drosophila Proteins
• Nerve Tissue Proteins
• Longevity
• Mutation