Article
Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology.
Molecular psychiatry - 1 Aug 2016
Readhead B, Haure-Mirande J-V, Zhang B, Haroutunian V, Gandy S, Schadt E E, Dudley J T, Ehrlich M E
Abstract excerpt
Identification and characterization of molecular mechanisms that connect genetic risk factors to initiation and evolution of disease pathophysiology represent major goals and opportunities for improving therapeutic and diagnostic outcomes in Alzheimer's disease (AD). Integrative genomic analysis of the human AD brain transcriptome holds potential for revealing novel mechanisms of dysfunction that underlie the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.