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Article

Knockdown of APPL mimics transgenic Aβ induced neurodegenerative phenotypes in Drosophila.

Neuroscience letters - 1 May 2017

Singh Sandeep Kumar, Srivastav Saurabh, Yadav Amarish Kumar, Srikrishna Saripella

Abstract excerpt

A variety of Drosophila mutant lines have been established as potential disease-models to study various disease mechanisms including human neurodegenerative diseases like Alzheimer's disease (AD), Huntington's disease (HD) and Parkinson's disease (PD). The evolutionary conservation of APP (Amyloid Precursor Protein) and APPL (Amyloid Precursor Protein-Like) and the comparable detrimental effects caused by their...

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Source

Identifiers

PMID: 28336338
DOI: 10.1016/j.neulet.2017.03.030

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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