Article
Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.
Acta neuropathologica - 1 Jun 2017
Chapuis Julien, Flaig Amandine, Grenier-Boley Benjamin, Eysert Fanny, Pottiez Virginie, Deloison Gaspard, Vandeputte Alexandre, Ayral Anne-Marie, Mendes Tiago, Desai Shruti, Goate Alison M, Kauwe John S K, Leroux Florence, Herledan Adrien, Demiautte Florie, Bauer Charlotte, Checler Fréderic, Petersen Ronald C, Blennow Kaj, Zetterberg Henrik, Minthon Lennart, Van Deerlin Vivianna M, Lee Virginia Man-Yee, Shaw Leslie M, Trojanowski John Q, Albert Marilyn, Moghekar Abhay, O'Brien Richard, Peskind Elaine R, Malmanche Nicolas, Schellenberg Gerard D, Dourlen Pierre, Song Ok-Ryul, Cruchaga Carlos, Amouyel Philippe, Deprez Benoit, Brodin Priscille, Lambert Jean-Charles
Abstract excerpt
Genome-wide association studies (GWASs) have identified 19 susceptibility loci for Alzheimer's disease (AD). However, understanding how these genes are involved in the pathophysiology of AD is one of the main challenges of the "post-GWAS" era. At least 123 genes are located within the 19 susceptibility loci; hence, a conventional approach (studying the genes one by one) would not be time- and cost-effective. We...
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