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The Drosophila amyloid precursor protein homologue mediates neuronal survival and neuroglial interactions

8 Dec 2020

Abstract excerpt

The amyloid precursor protein (APP) is a structurally and functionally conserved transmembrane protein whose physiological role in adult brain function and health is still unclear. Because mutations in APP cause familial Alzheimer's disease (fAD), most research focuses on this aspect of APP biology. We investigated the physiological function of APP in the adult brain using the fruit fly Drosophila melanogaster,...

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PMID: 33290404
DOI: 10.1371/journal.pbio.3000703

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