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Protein phosphatase 2A, complement component 4, and <i>APOE</i> genotype linked to Alzheimer’s disease using a systems biology approach

2020-11-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Recent reports suggest that the rare apolipoprotein E ( APOE ) Christchurch mutation and ε2 allele protect against Alzheimer’s disease (AD) pathology by reducing the burden of tau pathology. However, the mechanism(s) underlying the ε2 protective effect linking to tau is largely unknown. <h4>Methods</h4> The role of the ε2 allele in Alzheimer’s disease (AD) was investigated a g...

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Literature Corpus work
c8c581a2-91b3-5ea8-b8a6-3d3f3d27fb06
DOI
10.1101/2020.11.20.20235051
Open publication

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Protein phosphatase 2A, complement component 4, and <i>APOE</i> genotype linked to Alzheimer’s disease using a systems biology approachDOI 10.1101/2020.11.20.20235051
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