Article

Proteomic signatures of the <i>APOE ε4</i> and <i>APOE ε2</i> genetic variants and Alzheimer’s disease

2025-08-06

Abstract excerpt

The ε4 and ε2 alleles of the Apolipoprotein E ( APOE ) gene confer opposite genetic risks for Alzheimer’s disease (AD), but their underlying molecular mechanisms remain poorly characterized in humans. To resolve this, we systematically profiled APOE -associated proteomic alterations across five cohorts—including the Global Neurodegeneration Proteomics Consortium (GNPC), BioFINDER-2, the Alzheimer’s Disease Neuroim...

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Literature Corpus work: 6c8cb63d-f497-548d-82e1-ee654d537a97
DOI: 10.1101/2025.08.04.25332945

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