Article

<i>APOE</i>Genotype-specific Methylation Patterns are Linked to Alzheimer Disease Pathology and Estrogen Response

2022-12-22

Abstract excerpt

The joint effects of APOE genotype and DNA methylation on Alzheimer disease (AD) risk is relatively unknown. We conducted genome-wide methylation analyses using 2,021 samples in blood (91 AD cases, 329 mild cognitive impairment, 1,391 controls) and 697 samples in brain (417 AD cases, 280 controls). We identified differentially methylated levels in AD compared to controls in an APOE genotype-specific manner at 25 c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: da9d79df-a124-540e-91cd-cda82c66fe2d
DOI: 10.1101/2022.12.20.22283744

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>APOE</i>Genotype-specific Methylation Patterns are Linked to Alzheimer Disease Pathology and Estrogen ResponseDOI 10.1101/2022.12.20.22283744Read

APOE genotype-specific methylation patterns are linked to Alzheimer disease pathology and estrogen response.Semantic proximity Read

Identification of epigenome-wide DNA methylation differences between carriers of <i>APOE</i> ε4 and <i>APOE</i> ε2Semantic proximity Read

Haplotype-Resolved DNA Methylation at the <i>APOE</i> Locus identifies Allele-Specific Epigenetic Signatures Relevant to Alzheimer’s Disease RiskSemantic proximity Read

The APOE Gene is Differentially Methylated in Alzheimer's Disease.Semantic proximity Read

Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles.Semantic proximity Read

Whole genome methylation sequencing in blood identifies extensive differential DNA methylation in late‐onset dementia due to Alzheimer's diseaseSemantic proximity Read

Epigenomics of Alzheimer's disease.Semantic proximity Read

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s diseaseSemantic proximity Read

Beyond the Genotype: A Multi-Omic Analysis of APOEe4’s Role in Alzheimer’s DiseaseSemantic proximity Read

Epigenetic genes are differentially methylated in the blood of persons with mild cognitive impairment and Alzheimer’s diseaseSemantic proximity Read

Epigenome-wide association study of Alzheimer’s disease replicates 22 differentially methylated positions and 30 differentially methylated regionsSemantic proximity Read

DNA methylation in the APOE gene: its link with Alzheimer’s and cardiovascular healthSemantic proximity Read