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Protein phosphatase 2A and complement component 4 are linked to the protective effect of <i>APOE</i> ɛ2 for Alzheimer's disease

9 Feb 2022

Abstract excerpt

Abstract Introduction The apolipoprotein E ( APOE ) ɛ2 allele reduces risk against Alzheimer's disease (AD) but mechanisms underlying this effect are largely unknown. Methods We conducted a genome‐wide association study for AD among 2096 ɛ2 carriers. The potential role of the top‐ranked gene and complement 4 (C4) proteins, which were previously linked to AD in ɛ2 carriers, was investigated using human isogenic...

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PMID: 35142023
DOI: 10.1002/alz.12607

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