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Causal associations between potentially modifiable risk factors and the Alzheimer’s disease phenome: A Mendelian randomization study

2019-07-02

Abstract excerpt

<h4>Objective</h4> To evaluate the causal association of 22 previously reported risk factors for Alzheimer’s disease (AD) on the “AD phenome”: AD, AD age of onset (AAOS), hippocampal volume, cortical surface area and thickness, cerebrospinal fluid (CSF) levels of Aβ 42 , tau, and ptau 181 , and the neuropathological burden of neuritic plaques, neurofibrillary tangles, and vascular brain injury (VBI). <h4>Metho...

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Literature Corpus work
1fd944cc-dcd0-5439-b1eb-8bcaaf0eac52
DOI
10.1101/689752
Open publication

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