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Integrative Brain Transcriptome Analysis Links Complement Component 4 and<i>HSPA2</i>to the<i>APOE</i>ε2 Protective Effect in Alzheimer Disease

2020-11-24

Abstract excerpt

Mechanisms underlying the protective effect of apolipoprotein E ( APOE ) ε2 against Alzheimer’s disease (AD) are not well understood. We analyzed gene expression data derived from autopsied brains donated by 982 individuals including 135 APOE ε 2/ε 3 carriers. Complement pathway genes C4A and C4B were among the most significantly differentially expressed genes between ε 2/ε 3 AD cases and controls. We also identif...

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Literature Corpus work
881f4f0b-d887-5d31-aaf7-910ac0f824ab
DOI
10.1101/2020.11.23.20235762
Open publication

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Integrative Brain Transcriptome Analysis Links Complement Component 4 and<i>HSPA2</i>to the<i>APOE</i>ε2 Protective Effect in Alzheimer DiseaseDOI 10.1101/2020.11.23.20235762
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