Article

<i>APOE</i> *4 Risk-Modifying Genes and Drug Targets in Alzheimer’s Disease through Cell-Type Specific Genomic Analyses

2025-12-04

Abstract excerpt

<h4>Importance</h4> APOE *4 is the strongest, common genetic risk factor for late-onset Alzheimer’s disease (AD) with widespread and cell-type-specific impact on disease pathogenesis. Genetics and omics studies can help identify genes that counteract the effects of APOE *4, but so far have remained relatively small and crucially did not assess genetic findings through a cell-type-specific framework. <h4>Objecti...

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Literature Corpus work: a214b2b8-0bd0-5ce4-b1b9-a50c5092c4bc
DOI: 10.64898/2025.12.02.25341367

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