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Article

Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease.

Alzheimer's research & therapy - 9 Feb 2022

Panitch Rebecca, Hu Junming, Xia Weiming, Bennett David A, Stein Thor D, Farrer Lindsay A, Jun Gyungah R

Abstract excerpt

BACKGROUND: While Alzheimer disease (AD) is generally considered as a brain disorder, blood biomarkers may be useful for the diagnosis and prediction of AD brain pathology. The APOE ε4 allele has shown cerebrovascular effects including acceleration of blood-brain barrier (BBB) breakdown. METHODS: We evaluated the differential expression of previously established AD genes in brains from 344 pathologically...

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Source

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Identifiers

PMID: 35139885
DOI: 10.1186/s13195-022-00975-z
PMCID: PMC8830081

Genes

APOE
FRAS1
INPP5D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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