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Article

APOE genotype-specific methylation patterns are linked to Alzheimer disease pathology and estrogen response.

Translational psychiatry - 29 Feb 2024

Panitch Rebecca, Sahelijo Nathan, Hu Junming, Nho Kwangsik, Bennett David A, Lunetta Kathryn L, Au Rhoda, Stein Thor D, Farrer Lindsay A, Jun Gyungah R

Abstract excerpt

The joint effects of APOE genotype and DNA methylation on Alzheimer disease (AD) risk is relatively unknown. We conducted genome-wide methylation analyses using 2,021 samples in blood (91 AD cases, 329 mild cognitive impairment, 1,391 controls) and 697 samples in brain (417 AD cases, 280 controls). We identified differentially methylated levels in AD compared to controls in an APOE genotype-specific manner at 25...

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Identifiers

PMID: 38424036
DOI: 10.1038/s41398-024-02834-x
PMCID: PMC10904829

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