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Blood and Brain Transcriptome Analysis Reveals APOE Genotype-mediated and Immune-related Pathways Involved in Alzheimer Disease

2021-09-17

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<title>Abstract</title> <p>Background: While Alzheimer disease (AD) is generally considered as a brain disorder, blood biomarkers may be useful for diagnosis and prediction of AD brain pathology. The APOE ε4 allele has shown cerebrovascular effects including acceleration of blood brain barrier breakdown. <h4>Methods:</h4> We evaluated differential expression of previously established AD genes in brains from 344 p...

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Literature Corpus work
6ab1fff0-c96a-5794-bf32-9faa7d490790
DOI
10.21203/rs.3.rs-892590/v1
Open publication

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Blood and Brain Transcriptome Analysis Reveals APOE Genotype-mediated and Immune-related Pathways Involved in Alzheimer DiseaseDOI 10.21203/rs.3.rs-892590/v1
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