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Beyond the Genotype: A Multi-Omic Analysis of APOEe4’s Role in Alzheimer’s Disease

2025-10-16

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is characterized by widespread molecular dysregulation, with the APOEe4 allele recognized as its strongest genetic risk factor. However, the mechanisms by which APOEe4 drives distinct molecular changes – whether by exacerbating pathology or triggering compensatory responses – remain incompletely understood. We generated and analyzed proteomic, epigenetic, and genetic dat...

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Literature Corpus work: d4f1a76d-5201-564a-b378-d07326e944db
DOI: 10.1101/2025.10.16.682426

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