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Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on alzheimer’s disease risk in humans

2020-09-29

Abstract excerpt

<h4>INTRODUCTION</h4> Not all APOE ε4 carriers who survive to advanced age develop Alzheimer’s disease (AD); factors attenuating the risk of ε4 on AD may exist. <h4>METHODS</h4> Guided by the top ε4-attenuating signals from methylome-wide association analyses (N=572, ε4+ and ε4-) of neurofibrillary tangles and neuritic plaques, we conducted a meta-analysis for pathological AD within the ε4+ subgroups (N=235) a...

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Literature Corpus work
1718eba0-b89c-5c6d-890f-0b28bfc7ba2b
DOI
10.1101/2020.09.28.317156
Open publication

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Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on alzheimer’s disease risk in humansDOI 10.1101/2020.09.28.317156
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